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376. Gilgun-Sherki, Y., Melamed, E., Mechoulam, R. & Offen, D. The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6- hydroxydopamine-lesioned rats. Pharmacol Toxicol 93, 66-70 (2003).

377. Radbruch, L. & Nauck, F. [A review of side effects and complications with cannabinoid treatment]. Schmerz 17, 274-279 (2003).

378. Glaser, S. T. et al. Evidence against the presence of an anandamide transporter. Proc Natl Acad Sci U S A 100, 4269-4274 (2003).

379. Jonsson, K. O. et al. AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch Toxicol 77, 201-207 (2003).

380. Hinz, B., Ramer, R. & Brune, K. Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide. Adv Exp Med Biol 525, 145- 152 (2003).

381. Grotenhermen, F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 42, 327-360 (2003).

382. Croxford, J. L. Therapeutic potential of cannabinoids in CNS disease. CNS Drugs 17, 179-202 (2003).

383. Reggio, P. H. Pharmacophores for ligand recognition and activation/inactivation of the cannabinoid receptors. Curr Pharm Des 9, 1607-1633 (2003).

384. Cannabis-based medicines-GW pharmaceuticals: high CBD, high THC, medicinal cannabis--GW pharmaceuticals, THC:CBD. Drugs R D 4, 306-309 (2003).

385. Gallily, R. et al. Gamma-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells. Leuk Lymphoma 44, 1767-1773 (2003).

386. Gomez Del Pulgar, T., De Ceballos, M. L., Guzman, M. & Velasco, G. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 277, 36527- 36533 (2002).

387. Kozak, K. R. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277, 44877-44885 (2002).

388. Hashibe, M., Ford, D. E. & Zhang, Z. F. Marijuana smoking and head and neck cancer. J Clin Pharmacol 42, 103S-107S (2002).

389. Rubovitch, V., Gafni, M. & Sarne, Y. The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells. Brain Res Mol Brain Res 101, 93-102 (2002).

390. Hinnebusch, B. F., Meng, S., Wu, J. T., Archer, S. Y. & Hodin, R. A. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132, 1012-1017 (2002).

391. Inui, A. Cancer anorexia-cachexia syndrome: current issues in research and management. CA Cancer J Clin 52, 72-91 (2002).

392. Carter, G. T. & Weydt, P. Cannabis: old medicine with new promise for neurological disorders. Curr Opin Investig Drugs 3, 437-440 (2002).

393. Germain, N., Boichot, E., Advenier, C., Berdyshev, E. V. & Lagente, V. Effect of the cannabinoid receptor ligand, WIN 55,212-2, on superoxide anion and TNF- alpha production by human mononuclear cells. Int Immunopharmacol 2, 537-543 (2002).

394. Smith, P. F. Cannabinoids in the treatment of pain and spasticity in multiple sclerosis. Curr Opin Investig Drugs 3, 859-864 (2002).

395. Bifulco, M. & Di Marzo, V. Targeting the endocannabinoid system in cancer therapy: a call for further research. Nat Med 8, 547-550 (2002).

396. Sarafian, T. A., Kouyoumjian, S., Tashkin, D. & Roth, M. D. Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisole. Toxicol Lett 133, 171-179 (2002).

397. McKallip, R. J. et al. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100, 627-634 (2002).

398. Parolaro, D., Massi, P., Rubino, T. & Monti, E. Endocannabinoids in the immune system and cancer. Prostaglandins Leukot Essent Fatty Acids 66, 319-332 (2002).

399. Fernandez-Ruiz, J., Lastres-Becker, I., Cabranes, A., Gonzalez, S. & Ramos, J. A. Endocannabinoids and basal ganglia functionality. Prostaglandins Leukot Essent Fatty Acids 66, 257-267 (2002).

400. Kozak, K. R. & Marnett, L. J. Oxidative metabolism of endocannabinoids. Prostaglandins Leukot Essent Fatty Acids 66, 211-220 (2002).

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